2026-06-23T14:26:58Zhttps://www.radar-service.eu/oai/OAIHandler10.35097/kapcf985935rnu2g2026-04-23T13:34:49Zradar4kit
10.35097/kapcf985935rnu2g
Lehmkuhl, Sören
Sören
Lehmkuhl
0000-0002-1321-7677
Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
Fleischer, Simon
Simon
Fleischer
0000-0003-3554-8888
Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
Yang, Jing
Jing
Yang
0009-0007-4956-5853
Chekmenev, Eduard Y.
Eduard Y.
Chekmenev
Theis, Thomas
Thomas
Theis
Appelt, Stephan
Stephan
Appelt
Korvink, Jan G.
Jan G.
Korvink
Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
Jouda, Mazin
Mazin
Jouda
0000-0002-1226-1174
Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
Rapid RASER MRI - Data
Karlsruhe Institute of Technology
2026
2026
Engineering
Open Access
Creative Commons Attribution 4.0 International
Lehmkuhl, Sören
0000-0002-1321-7677
Fleischer, Simon
0000-0003-3554-8888
Yang, Jing
0009-0007-4956-5853
Chekmenev, Eduard Y.
Theis, Thomas
Appelt, Stephan
Korvink, Jan G.
Jouda, Mazin
0000-0002-1226-1174
Conventional Magnetic Resonance Imaging (MRI) relies on high‐power Radio‐Frequency (RF) pulses to excite nuclear spins and in turn generate NMR signals. These pulses require large high‐power RF‐amplifiers and cause heat deposition in the tissue, which must be minimized for safety, presenting a growing problem when moving toward ever‐higher field MRI. An alternative to RF‐pulse excitation is self‐excitation of nuclear spins using Radiofrequency Amplification by Stimulated Emission of Radiation (RASER), where the nuclear spins undergo spontaneous transition, without RF excitation, from an over‐populated state to a ground state. Here, the feasibility of recording rapid proton RASER MRI images of pyrazine at low concentration (120 mM) with large matrix (128x128 pixels) in as little as 78 ms is demonstrated at 500 MHz (11.7 T). We also recorded a time‐series of images using a single bolus hyperpolarized pyrazine highlighting the feasibility of dynamic tracking. The demonstrated approach allows recording MRI scans without transmit‐receive electronics of the MRI scanner, which is highly desirable for portable MRI as well as the emerging field of hyperpolarized MRI using, e.g., HP protons, 129Xe gas or HP 13C labeled biomolecules as molecular tracers and imaging agents.
Included are 1H MRI data recorded on a 500 MHz Avance NEO spectrometer (Bruker), using thermal equilibrium polarization, SABRE hyperpolarization and RASER excitation. Data is provided in PV360-3.2 format, BIDS and as PNG images. For more information, see the linked publication
https://publikationen.bibliothek.kit.edu/1000189583
86,4 MB
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