Alternativer Identifier:
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Verwandter Identifier:
(Is Supplement To) 10.1002/bimj.201700219 - DOI
Ersteller/Autor:
Melzer, Nina [Leibniz Institute for Farm Animal Biology (FBN)] https://orcid.org/0000-0002-9586-1588
Wittenburg, Dörte [Leibniz Institute for Farm Animal Biology (FBN)] https://orcid.org/0000-0002-3639-2574
Beitragende:
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Weitere Titel:
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Beschreibung:
(Abstract) A simulation study has been conducted to analyse the association between genetic and phenotypic variation in livestock. Following the density and distribution of single nucleotide polymorphisms (SNPs) on the Illumina BovineSNP50 chip, 52,773 SNPs were simulated on the cattle genome of 30 Morgan length. Several generations of random mating were executed in which random recombination events according to the genetic distance between SNPs and random mutation of SNP alleles were considered. In the most recent generations, 50 sires were mated to 20 dams in order to generate multiple half-sib families. The data were split into training (n=2,000) and validation/testing set (n=2,000). Twenty-three SNPs were randomly preselected to be the causative variants, and additive, dominance and epistatic effects were simulated. Two different traits were achieved by adding different residual error terms to the sum of genetic effects, such that the total genetic variation contributed either 30% or 50% to the phenotypic variation. Then, 5,227 SNPs (every 10-th SNP including the causative variants) were selected. The simulation was repeated 100 times. More details can be found in Wittenburg et al. (2011) Including non-additive genetic effects in Bayesian methods for the prediction of genetic values based on genome-wide markers. BMC Genetics 12:74, https://doi.org/10.1186/1471-2156-12-74
Schlagworte:
SNP, dominance, epistasis, recombination, genetic variation
Zugehörige Informationen:
FUGATO-plus Project "BovIBI"
Sprache:
-
Herausgeber:
Leibniz Institute for Farm Animal Biology (FBN)
Erstellungsjahr:
Fachgebiet:
Agriculture
Biology
Genetics
Life Science
Objekttyp:
(Dataset) phenotypic and genetic data
Datenquelle:
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Verwendete Software:
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Datenverarbeitung:
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Erscheinungsjahr:
Rechteinhaber:
Leibniz Institute for Farm Animal Biology (FBN)
Förderung:
Federal Ministry of Education and Research (BMBF) - (0315137)
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radarfbn
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Archivierungsdatum:
2018-05-25
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6,3 GB
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radarfbn
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5c2bcc8a7a524ed0d90ba5cbeb198dbd (MD5)
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Publikationsdatum: 2018-05-25
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Dieses Werk ist lizenziert unter
CC BY 4.0 Attribution
Datenpaket zitieren
Melzer, Nina; Wittenburg, Dörte (2018): Supplementary data to publication “An approximate Bayesian significance test for genomic evaluations” (Biom J). Leibniz Institute for Farm Animal Biology (FBN).