Alternate identifier:
-
Related identifier:
(Is Supplement To) 10.1002/bimj.201700219 - DOI
Creator/Author:
Melzer, Nina https://orcid.org/0000-0002-9586-1588 [Leibniz Institute for Farm Animal Biology (FBN)]

Wittenburg, Dörte https://orcid.org/0000-0002-3639-2574 [Leibniz Institute for Farm Animal Biology (FBN)]
Contributors:
-
Title:
Supplementary data to publication “An approximate Bayesian significance test for genomic evaluations” (Biom J)
Additional titles:
-
Description:
(Abstract) A simulation study has been conducted to analyse the association between genetic and phenotypic variation in livestock. Following the density and distribution of single nucleotide polymorphisms (SNPs) on the Illumina BovineSNP50 chip, 52,773 SNPs were simulated on the cattle genome of 30 Morgan length. Several generations of random mating were executed in which random recombination events according to the genetic distance between SNPs and random mutation of SNP alleles were considered. In the most recent generations, 50 sires were mated to 20 dams in order to generate multiple half-sib families. The data were split into training (n=2,000) and validation/testing set (n=2,000). Twenty-three SNPs were randomly preselected to be the causative variants, and additive, dominance and epistatic effects were simulated. Two different traits were achieved by adding different residual error terms to the sum of genetic effects, such that the total genetic variation contributed either 30% or 50% to the phenotypic variation. Then, 5,227 SNPs (every 10-th SNP including the causative variants) were selected. The simulation was repeated 100 times. More details can be found in Wittenburg et al. (2011) Including non-additive genetic effects in Bayesian methods for the prediction of genetic values based on genome-wide markers. BMC Genetics 12:74, https://doi.org/10.1186/1471-2156-12-74
Keywords:
SNP, dominance, epistasis, recombination, genetic variation
Related information:
FUGATO-plus Project "BovIBI"
Language:
-
Publishers:
Leibniz Institute for Farm Animal Biology (FBN)
Production year:
Subject areas:
Agriculture
Biology
Genetics
Life Science
Resource type:
(Dataset) phenotypic and genetic data
Data source:
-
Software used:
-
Data processing:
-
Publication year:
Rights holders:
Leibniz Institute for Farm Animal Biology (FBN)
Funding:
Federal Ministry of Education and Research (BMBF) - (0315137)
Name Storage Metadata Upload Action

Number of views in the previous six months.

Dataset page views

230


Downloads

0


Overall statistics

Period Landing page accessed Dataset downloaded
Apr 2024 35 0
Mar 2024 34 0
Feb 2024 38 0
Jan 2024 43 0
Dec 2023 39 0
Nov 2023 41 0
Before 1701 47
Total 1931 47
Status:
Published
Uploaded by:
radarfbn
Created on:
Archiving date:
2018-05-25
Archive size:
6.3 GB
Archive creator:
radarfbn
Archive checksum:
5c2bcc8a7a524ed0d90ba5cbeb198dbd (MD5)
Embargo end date:
-